Clinical Biochemistry

Clinical biochemistry focuses on the analysis of bodily fluids for diagnosis and is an area of clinical pathology focusing on the diagnosis and management of disease.
Clinical Biochemistry

Water purification systems are used to feed many different functions within clinical analyzers, such as:

  • Washing reaction cuvettes
  • Feeding wash stations for probes and stirrer paddles
  • Diluting reagents, samples and detergents
  • Incubator baths
  • An interface between syringe and sample

The most important aspect of water for automated pathology analysers is reliability, and therefore must be compliant with a the appropriate water quality standards such as CLRW.

Impact of Water

Water quality is extremely important in clinical diagnostics and biochemistry. Not only will the chemistry of the tests be affected, but impure water could affect the general operation of the analyzer, reducing the reliability of test results.

  • Reduce the accuracy of pipetting volume due to particles and bacteria
  • Errors in photometric readings as a result of particles interfering when a water bath is used
  • Cuvette washing contamination, carryover and water marks
  • Sample and reagent probe washing contamination and carryover
  • Affect sample and dilution leading to errors and poor reagent stability
  • As a zero standard (Ca+, Mg2+, PO43-, HCO3- etc.) calibration stability and sensitivity is reduced
  • In immunoassay systems, bacterial by-products such as alkaline phosphatase, can interfere with some enzyme based assay results 

Water Requirements

Make sure that you are using the right water type for your application. Here are the requirements for various cell culture applications.

  Sensitivity required Resistivity 
(MΩ.cm)*
TOC 
(ppb)
Filter 
(µm)
Bacteria (CFU/ml) Endotoxins (EU/ml) Nucleases Water grade
Clinical biochemistry

USP/EP

CLSI

>2

>10

<500 <0.2 <1 NA NA I
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